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Tranylcypromine sulfate

Tranylcypromine sulfate structure

CAS No:
13492-01-8
Formula:
C9H11N.¹/2H2O4S
Chemical Name:
Tranylcypromine sulfate
Synonyms:
Cyclopropanamine,2-phenyl-,(1R,2S)-rel-,sulfate (2:1);Cyclopropylamine,2-phenyl-,sulfate (2:1),trans-(±)-;Cyclopropanamine,2-phenyl-,trans-(±)-,sulfate (2:1);Parnate;Tranylcypromine sulfate;dl-Tranylcypromine sulfate;Tylciprine;trans-2-Phenylcyclopropanamine sulfate (2:1);Cyclopropanamine,2-phenyl-,trans-,sulfate (2:1);Parnetil;trans-2-Phenylcyclopropylamine hemisulfate;1949-18-4;7081-36-9
Categories:
Analytical Chemistry > Standard

Description

Tranylcypromine hemisulfate is an irreversible, nonselective MAO inhibitor used in the treatment of depression.

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)

Tranylcypromine sulfate Basic Attributes

Molecular Weight：

364.46

Exact Mass：

364.14567842

EC Number：

236-807-1

Characteristics

Density：

1.065g/cm3

Flash Point：

90.8ºC

Water Solubility：

soluble in water; very slightly soluble in ethanol (96%) and in ether .

Storage Conditions：

2-8°C

Safety Information

Packing level：

Ⅱ

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 2

wgk germany：

hazard class code：

23/24/25

safety instructions：

36/37/39-45

RTECS Number：

GZ2625000

Marks：

Precautionary statement(s)：

P261-P264-P280-P301 + P310-P311

Hazard Statements：

H300-H311-H331

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)|Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

MeSH Entry Terms：

Jatrosom

Tranylcypromine sulfate Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:364.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:364.14567842
Monoisotopic Mass:364.14567842
Topological Polar Surface Area:135
Heavy Atom Count:25
Complexity:197
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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tranylcyprominesulfate tranylcyprominesulphate TRANYLCYPROMINE HEMISULFATE Tranylcypromine hemisulfate Tranylcypromine Sulfate (125 mg) TRANS-2-PHENYL

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