1-Amino-4-methylpiperazine
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1-Amino-4-methylpiperazine
structure -
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CAS No:
6928-85-4
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Formula:
C5H13N3
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Chemical Name:
1-Amino-4-methylpiperazine
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Synonyms:
1-Piperazinamine,4-methyl-;Piperazine,1-amino-4-methyl-;4-Methyl-1-piperazinamine;1-Amino-4-methylpiperazine;1-Methyl-4-aminopiperazine;4-Methyl-1-aminopiperazine;N-Amino-N′-methylpiperazine;N1-Methyl-N4-aminopiperazine;NSC 80649;(4-Methylpiperazin-1-yl)amine;4-Amino-1-methylpiperazine;2135319-59-2
- Categories:
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CAS No:
1-Amino-4-methylpiperazine Basic Attributes
115.18
115.18
103334
230-053-7
J5GBT1LFT2
80649
DTXSID3057808
29335995
Characteristics
32.5
-1.39
Clear Viscous Solution
1.0±0.1 g/cm3
172-175 °C @ Press: 760 Torr
62 °C
1.495
Micible with water.
Store at +2°C to +8°C.
Safety Information
III
3
2733
3
36/37/38-20/21/22
24/25-36-26
Xi,Xn
Stable at room temperature in closed containers under normal storage and handling conditions. Air sensitive Light sensitive.
P261-P280-P305 + P351 + P338
H302 + H312 + H332-H315-H319-H335
|Warning|H302 (43.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 90 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Amino-4-methylpiperazine Use and Manufacturing
Using piperazine hexahydrate as raw material, it is obtained through steps of methylation, hydrolysis, nitrosation, reduction, etc. (1) Methylation: Dissolve piperazine hexahydrate in formic acid, suck into the reaction pot, raise the temperature to 90°C, add formaldehyde dropwise with stirring for about 1h, after the addition, keep the reaction at 90-95°C for 1h, and evaporate under reduced pressure Water and excess raw materials to obtain methyl formyl piperazine concentrate. (2) Hydrolysis. Add hydrochloric acid and water to the above concentrated solution, stir and heat to 105°C, reflux for 2h. Distill under reduced pressure until there is no distillate, discard the distilled acid, and cool the remaining liquid to 15°C, let it stand overnight, and filter. The filtrate is methylpiperazine hydrochloride solution. (3) Nitrosation The filtrate obtained in the hydrolysis step was added dropwise with sodium nitrite solution at 30°C, after the addition, the reaction was kept for 30 minutes to obtain the methyl nitropiperazine product liquid. (4) Reduction: Add glacial acetic acid to the nitrosation product solution, cool it, gradually add zinc powder at 30-40°C, and after the addition, keep it at 30-40°C for 1.5h, cool to about 15°C, leave it overnight, and filter. . Add this reduction filtrate to an alkalization pot that has been pre-configured with liquid caustic soda and is cooled to below 10°C, and then is fully cooled and then sent to the extraction pot. Chloroform is added in 3 times for extraction, and the chloroform extracts are combined, and the chloroform is recovered by atmospheric distillation , When the liquid temperature is 85℃, it is transferred to the rectifying pot, firstly distilled under normal pressure to the liquid temperature of 135℃, and then subjected to vacuum distillation. Collect the distillate at 120℃ (5.33-8.0kPa) to be 1-amino-4- Methylpiperazine. The total yield of the above four steps is about 30%. Raw material consumption quota: piperazine hexahydrate (95%) 1148.1kg/t, formic acid (85%) 2266.2kg/t, formaldehyde (37%) 1130.8kg/t, zinc powder (90%) 1900.2kg/t, glacial acetic acid 3759.4kg/t, concentrated hydrochloric acid 4046.5kg/t, sodium nitrite 937.6kg/t.
Pharmaceutical intermediates for the production of antibiotic rifampicin.
Computed Properties
Molecular Weight:115.18
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:115.110947427
Monoisotopic Mass:115.110947427
Topological Polar Surface Area:32.5
Heavy Atom Count:8
Complexity:66.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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