2-Methyl-3-(trifluoromethyl)aniline
-
2-Methyl-3-(trifluoromethyl)aniline
structure -
-
CAS No:
54396-44-0
-
Formula:
C8H8F3N
-
Chemical Name:
2-Methyl-3-(trifluoromethyl)aniline
-
Synonyms:
Benzenamine,2-methyl-3-(trifluoromethyl)-;2-Methyl-3-(trifluoromethyl)benzenamine;2-Methyl-3-(trifluoromethyl)aniline;3-(Trifluoromethyl)-2-methylaniline;2-Amino-6-(trifluoromethyl)toluene;2-Methyl-3-aminobenzotrifluoride;2-Methyl-3-(trifluoromethyl)phenylamine;3-(Trifluoromethyl)-2-methylbenzenamine
- Categories:
-
CAS No:
2-Methyl-3-(trifluoromethyl)aniline Basic Attributes
175.15
175.15
2832865
259-145-5
569607266B
DTXSID9057769
2921430090
Characteristics
26
2.5
White Crystalline Powder
1.2±0.1 g/cm3
38-42 °C(lit.)
62-64°C4mm
>210 °F
1.481
Safety Information
6.1
2811
3
36/37/38-26/27/28
26-36-24/25
Xi,T,T+
Toxic
P305 + P351 + P338
H315-H319-H335
|Danger|H302 (31.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P284, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 60 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Methyl-3-(trifluoromethyl)aniline Use and Manufacturing
Preparation of 2-Methyl-3-Trifluoromethyl-Aniline C. The CH2 Cl2 extracts are dried over K2 CO3 and evaporated to give 2-methyl-3-trifluoromethyl-aniline (MTA) (6.5 g, 96percent yield), an oil which solidifies on standing. STR13 iv.) A mixture of 2-methyl-3-trifluoromethylaniline (368 g, 2.1 moles) and 2-chloronicotinic acid (158.0 9, 1.0 mole) in 400 ml of water is heated at 100° C. for 24 hours together with p-toluenesulfonic acid (15.0 g) monohydrate as the acid catalyst. Potassium hydroxide (ca. 145 g) in water (255 ml) is added and the pH is maintained above 11. After diluting the reaction mixture to 1.2 liters with water, the mixture is cooled to 50° C., adjusted to pH 11, treated with 7 g of a decolorizing charcoal and 15 g of a filter aid, and clarified by filtration. The filtrate is diluted with 750 ml of water and the pH is adjusted to 5.0 with concentrated sulfuric acid.iii.) 2-methyl-3-trifluoromethylpivalanilide (10.0 g)is hydrolyzed by refluxing in concentrated HBr (40 ml, 48percent) for 3 hours. The mixture is cooled to 20° C. and poured onto ice-water (40.0 g). The pH is adjusted to 9 with concentrated NaOH and the mixture is extracted with two. 30 ml portions of CH2 Cl2. The CH2 Cl2 extracts are dried over K2 CO3 and evaporated to give 2-methyl-3-trifluoromethyl-aniline (MTA) (6.5 g, 96percent yield), an oil which solidifies on standing. STR13Following the procedure of Example 1, the following substituted aniline compounds:...3-fluoro-2-methylaniline3-iodo-2-methylaniline3-trifluoromethyl-2-methylaniline560 g of 6-chloro-2-chloromethyl-3-trifluoromethylaniline hydrochloride was weighed into a pressure reactor, and ethanol, a catalyst Pd/C, and a base were added. The air in the system was replaced with hydrogen, and the system was reacted under a pressure of 4 kg of hydrogen for 48 hours, cooled, filtered, solvent-removed, and the residue was distilled under reduced pressure to obtain 262 g of a crystalline solid. The yield was 75percent, and the purity of the GC was more than 99percent.General procedure: An equimolar mixture of General procedure: An equimolar mixture of
Computed Properties
Molecular Weight:175.15
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:175.06088375
Monoisotopic Mass:175.06088375
Topological Polar Surface Area:26
Heavy Atom Count:12
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Methyl-3-(trifluoromethyl)aniline
-
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Custom Synthetic Chemicals,Biological Stains,Pharmaceutical Intermediates,Cosmetic Grade Chemicals,Enzyme,Nucleosides,Indicators,Speciality Chemicals,Biological Chemicals,Enzyme Substrates -
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
6 YRS
Business licensed Certified factoryManufactory Supplier of Pharmaceutical intermediates -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals -
![China]()
CN
3 YRS
Business licensedTrader Supplier of CHEMICALS,REAGENTSInquiryCAS No.: 54396-44-0Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
Sodium alginate
9005-38-3
-
diethyl 2,2-dimethyl-1,3-dioxane-5,5-dicarboxylate
51335-75-2
-
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester, hydrochloride (1:1)
103733-33-1
-
Triethylmethylammonium chloride Formula
10052-47-8
-
Ethanedioic acid, calcium salt (1:1) Formula
563-72-4
-
Dibutyltin diacetate Formula
1067-33-0
-
1,6-Naphthalenedisulfonic acid, sodium salt (1:2) Structure
1655-43-2
-
Propylparaben sodium Structure
35285-69-9
-
What is Sodium laurate
629-25-4
-
What is N-Hydroxysulfosuccinimide sodium salt
106627-54-7
2-Methyl-3-(trifluoromethyl)aniline
SDSRequest for Quotation