3-Chloro-2-fluorobenzaldehyde
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3-Chloro-2-fluorobenzaldehyde
structure -
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CAS No:
85070-48-0
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Formula:
C7H4ClFO
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Chemical Name:
3-Chloro-2-fluorobenzaldehyde
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Synonyms:
Benzaldehyde,3-chloro-2-fluoro-;3-Chloro-2-fluorobenzaldehyde;2-Fluoro-3-chlorobenzaldehyde
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CAS No:
Safety Information
IRRITANT
3
36/37/38-20/21/22
26-36-37/39
Xi,Xn
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-Chloro-2-fluorobenzaldehyde Use and Manufacturing
1L four-necked flask, 36.3 g of sodium hydrogencarbonate, 500 g of dichloromethane, 0.5 g of ΤΕΜΡO, and the mixture was cooled to 0 to 5 ° C with stirring, 50 g of 2-fluoro-3-chlorobenzyl alcohol and 100 g of dichloromethane were added dropwise, and then add the sodium hypochlorite solution 230g, drop after the insulation reaction 1 h, sampling control, raw materials ≤ 1percent, stop the reaction, standing stratification, the oil layer of simple distillation of dichloromethane recovery, and then vacuum distillation that 2-fluoro-3-chlorobenzaldehyde 46.1 g, content 97.5percent, yield 91percent.
Computed Properties
Molecular Weight:158.56
XLogP3:2.1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:157.9934706
Monoisotopic Mass:157.9934706
Topological Polar Surface Area:17.1
Heavy Atom Count:10
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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