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AG 99

AG 99 structure

AG 99 

structure
  • CAS No:

    122520-85-8

  • Formula:

    C10H8N2O3

  • Chemical Name:

    AG 99

  • Synonyms:

    TYRPHOSTIN AG 99;TYRPHOSTIN B40;TYRPHOSTIN 46;TYRPHOSTIN A46;3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE;AG 99;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE

  • Categories:

    Biochemical Engineering  >  Amino Acids and Derivatives

Description

(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1].

AG 99 Basic Attributes

204.18

204.053497

Characteristics

107

0.4

1.482±0.06 g/cm3(Predicted)

247 °C

544.4±50.0 °C(Predicted)

283.0±30.1 °C

1.711

Desiccate at +4°C

Safety Information

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

H302

AG 99 Use and Manufacturing

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

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