Tyrphostin AG 213
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Tyrphostin AG 213
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CAS No:
122520-86-9
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Formula:
C10H8N2O2S
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Chemical Name:
Tyrphostin AG 213
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Synonyms:
2-Propenethioamide,2-cyano-3-(3,4-dihydroxyphenyl)-,(2E)-;2-Propenethioamide,2-cyano-3-(3,4-dihydroxyphenyl)-,(E)-;(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenethioamide;AG 213;Tyrphostin AG 213
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CAS No:
Description
3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.
Characteristics
122.36000
0.93
1.5±0.1 g/cm3
213 °C
474.5±55.0 °C at 760 mmHg
240.8±31.5 °C
1.780
DMSO: 50 mg/mL, clear, orange
2-8°C
Safety Information
3
36/37/38
26-36
Xi
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
3,4-dihydroxy-alpha-cyanothiocinnamide
Tyrphostin AG 213 Use and Manufacturing
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).
Computed Properties
Molecular Weight:220.25
XLogP3:1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:220.03064868
Monoisotopic Mass:220.03064868
Topological Polar Surface Area:122
Heavy Atom Count:15
Complexity:332
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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