2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
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2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
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CAS No:
73731-37-0
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Formula:
C19H19NO5
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Chemical Name:
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
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Synonyms:
FMOC-L-THREONINE extrapure;N-(9-Fluorenylmethoxycarbonyl)-L-threonine ,99%;N-alpha-(9-fluorenylmethyloxycarbonylamino)-3-hydroxybutanoic acid;Fmoc-L-threonine ,99%;Fmoc-L-Threonine monohydrate ,99%;Fmoc-Threonine-OH;2-(9H-Fluoren-9-ylMethoxycarbony-laMino)-3-;FMoc-Thr-OH·H2O FMoc-L-threonine Monohydrate
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CAS No:
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid Basic Attributes
341.36
341.126312
1533716-785-6
334300
DTXSID60513242
2924299090
Characteristics
95.9
2.4
White to off-white crystalline powder
1.3±0.1 g/cm3
115°C(dec.)
596.5°C at 760 mmHg
314.6±30.1 °C
1.618
2-8°C
-16 º (c=1%, DMF)
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid Use and Manufacturing
At r.t. a solution of FmocONSu (3.37 g, 10.0 mmol) in 25 mL of DioxaneGeneral procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.
Used in biochemical reagents and peptide synthesis.
Computed Properties
Molecular Weight:341.4
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:341.12632271
Monoisotopic Mass:341.12632271
Topological Polar Surface Area:95.9
Heavy Atom Count:25
Complexity:474
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
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