Fialuridine
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Fialuridine
structure -
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CAS No:
69123-98-4
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Formula:
C9H10FIN2O5
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Chemical Name:
Fialuridine
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Synonyms:
2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione;1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil;5-Iodo-2′-fluoroarauracil;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil;FIAU;Fialuridine;Fluoroiodoarauracil;NSC 678514;129049-36-1
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CAS No:
Description
Colourless crystals
Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU).|Fialuridine is a nucleoside analog of uridine with activity against hepatitis B virus and herpes viruses. Fialuridine inhibits viral DNA polymerase and viral replication.
Characteristics
99.1
-0.32
white to beige
2.2±0.1 g/cm3
216-217 °C
1.685
DMSO: soluble5mg/mL, clear (warmed)
Refrigerator
Safety Information
NONH for all modes of transport
3
24/25
YQ9512500
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)
1-(2'fluoro-2'-deoxyarabinofuranosyl)-5-iodouracil
Fialuridine Use and Manufacturing
An antiviral agent; nucleoside analog with antihepatitis B activity
Computed Properties
Molecular Weight:372.09
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:371.96185
Monoisotopic Mass:371.96185
Topological Polar Surface Area:99.1
Heavy Atom Count:18
Complexity:418
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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