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CHIR-124

CHIR-124 structure

CAS No:
405168-58-3
Formula:
C23H22ClN5O
Chemical Name:
CHIR-124
Synonyms:
CHIR-124;2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-;4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one
Categories:
Biochemical Engineering > Inhibitors

Description

CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.

CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

CHIR-124 Basic Attributes

Molecular Weight：

419.90668

Exact Mass：

419.151276

UNII：

5K64W8EU3E

Characteristics

PSA：

68.8

XLogP3：

3.86

Density：

1.5±0.1 g/cm3

Refractive Index：

1.750

Drug Information

MeSH Entry Terms：

((S)-3-(1H-benzo(d)imidazol-2-yl)-6-chloro-4-quinuclidin-3-ylamino)quinolin-2(1H)-one

Computed Properties

Molecular Weight:419.9
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:419.1512880
Monoisotopic Mass:419.1512880
Topological Polar Surface Area:73
Heavy Atom Count:30
Complexity:720
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CHIR-124

CAS No.: 405168-58-3

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