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Sildenafil

Sildenafil structure

CAS No:
139755-83-2
Formula:
C22H30N6O4S
Chemical Name:
Sildenafil
Synonyms:
7H-Pyrazolo[4,3-d]pyrimidin-7-one,5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-;Piperazine,1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-;1H-Pyrazolo[4,3-d]pyrimidine,piperazine deriv.;5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one;Sildenafil;5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;Revatio;Vizarsin;Patrex
Categories:
Biochemical Engineering > Inhibitors

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Description

Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.

Sildenafil Basic Attributes

Molecular Weight：

474.57600

Exact Mass：

474.58

EC Number：

604-158-7

HScode：

2933990090

Characteristics

PSA：

121.80000

XLogP3：

2.56750

Appearance：

Solid

Density：

1.39g/cm3

Melting Point：

188-190 °C

Boiling Point：

672.4ºC at 760 mmHg

Flash Point：

360.5ºC

Refractive Index：

1.664

Water Solubility：

In water, 4.665 mg/L at 25 deg C (est)

Storage Conditions：

Store in original container in a cool dark place.

Vapor Pressure：

6.1E-18mmHg at 25°C

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

hazard class code：

R36/37/38

safety instructions：

S22; S24/25; S36; S26

Marks：

Stability/Shelf Life：

Commercially available sildenafil citrate tablets has an expiration date of 24 months after the date of manufacture when stored as directed.

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

Sildenafil Use and Manufacturing

1. Antiviral
2. An orally active selective type 5 cGMP phosphodiesterase inhibitor.

Material

1-Methylpiperazine

Ethanol