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UNC2250

UNC2250 structure

CAS No:
1493694-70-4
Formula:
C24H36N6O2
Chemical Name:
UNC2250
Synonyms:
UNC2250;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanolUNC2250;UNC2250(UNC 2250)
Categories:
Biochemical Engineering > Inhibitors

Description

UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.IC50 Value: 9.8 nM [1]Target: Othersin vitro: UNC2250 is 160-fold more active for Mer versus Axl and 60-fold versus Tyro3. UNC2250 had a moderate half-life, clearance, and volume of distribution as well as reasonable oral bioavailability and good solubility and was thus chosen for characterization of kinase selectivity and further evaluat

UNC2250 Basic Attributes

Molecular Weight：

440.58164

Exact Mass：

440.289978

Characteristics

PSA：

95.4

XLogP3：

2.8

Density：

1.224±0.06 g/cm3(Predicted)

Boiling Point：

657.4±65.0 °C(Predicted)

Flash Point：

351.4±34.3 °C

Refractive Index：

1.626

Drug Information

MeSH Entry Terms：

UNC2250

Computed Properties

Molecular Weight:440.6
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:440.28997441
Monoisotopic Mass:440.28997441
Topological Polar Surface Area:95.4
Heavy Atom Count:32
Complexity:527
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes