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ARRY-380

ARRY-380 structure

CAS No:
937265-83-3
Formula:
C29H27N7O4S
Chemical Name:
ARRY-380
Synonyms:
ARRY-380;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine;ARRY-380-d3;N-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-Methylphenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine;HER2-Inhibitor-1;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine ARRY 380;Arry-380, >=98%;ARRY-380 (analog )
Categories:
Biochemical Engineering > Inhibitors

Description

The product is the analog of ARRY-380, ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR

ARRY-380 Basic Attributes

Molecular Weight：

569.63418

Exact Mass：

569.184509

EC Number：

-0

UNII：

H32S1659ED

DSSTox ID：

DTXSID00239555

Characteristics

PSA：

145

XLogP3：

3.59

Density：

1.4±0.1 g/cm3

Refractive Index：

1.709

Safety Information

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P309+P311, P314, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

ARRY-380 Use and Manufacturing

Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.

Computed Properties

Molecular Weight:569.6
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:569.18452354
Monoisotopic Mass:569.18452354
Topological Polar Surface Area:145
Heavy Atom Count:41
Complexity:954
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of ARRY-380

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazolin-4-amine

CAS No.: 937265-83-3

Content: 99.00%

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Arry-380

CAS No.: 937265-83-3

Content: 99%

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