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BMX-IN-1

BMX-IN-1 structure

CAS No:
1431525-23-3
Formula:
C29H24N4O4S
Chemical Name:
BMX-IN-1
Synonyms:
BMX kinase inhibitor;BMX-IN-1;N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide;N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide;henyl]-
Categories:
Biochemical Engineering > Inhibitors

Description

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

BMX-IN-1 Basic Attributes

Molecular Weight：

524.59026

Exact Mass：

524.151855

Characteristics

PSA：

117

XLogP3：

3.52

Density：

1.4±0.1 g/cm3

Refractive Index：

1.708

Drug Information

MeSH Entry Terms：

BMX-IN-1

Computed Properties

Molecular Weight:524.6
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:524.15182643
Monoisotopic Mass:524.15182643
Topological Polar Surface Area:117
Heavy Atom Count:38
Complexity:1030
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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BMX-IN-1

CAS No.: 1431525-23-3

Content: 0.982%

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