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UNC2881

UNC2881 structure

CAS No:
1493764-08-1
Formula:
C25H33N7O2
Chemical Name:
UNC2881
Synonyms:
UNC2881;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide;N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881;2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine
Categories:
Biochemical Engineering > Inhibitors

Description

UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. IC50 value: 22 nM [1]Target: Mer kinase inhibitorTreatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may ha

UNC2881 Basic Attributes

Molecular Weight：

463.57522

Exact Mass：

463.269562

Characteristics

PSA：

117

XLogP3：

3.8

Density：

1.3±0.1 g/cm3

Refractive Index：

1.666

Water Solubility：

H2O: Insuluble (1.7E-3 g/L) (25 ºC)

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

UNC2881

Computed Properties

Molecular Weight:463.6
XLogP3:3.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:463.26957332
Monoisotopic Mass:463.26957332
Topological Polar Surface Area:117
Heavy Atom Count:34
Complexity:608
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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UNC2881

CAS No.: 1493764-08-1

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