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BGB 324

BGB 324 structure

CAS No:
1037624-75-1
Formula:
C30H34N8
Chemical Name:
BGB 324
Synonyms:
1H-1,2,4-Triazole-3,5-diamine,1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-;1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine;R 428;1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7-(S)-pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl]-1H-1,2,4-triazole-3,5-diamine;BGB 324;Bemcentinib;1H-1,2,4-Triazole-3,5-diamine 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-;1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[7(S)-(1-pyrrolidinyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine
Categories:
Biochemical Engineering > Inhibitors

Description

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM.

Molecular Weight：

506.64456

Exact Mass：

506.64

PSA：

97.8

XLogP3：

5.5

Density：

1.41±0.1 g/cm3(Predicted)

Boiling Point：

799.6±70.0 °C(Predicted)

Flash Point：

437.4±35.7 °C

Refractive Index：

1.768

Water Solubility：

H2O: Insuluble (5.6E-5 g/L) (25 ºC)

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R428

CAS No.: 1037624-75-1

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