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ARRY-334543

ARRY-334543 structure

CAS No:
845272-21-1
Formula:
C22H19ClN6O2S
Chemical Name:
ARRY-334543
Synonyms:
ARRY-334543;AR-00334543;Varlitinib;(R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline;(R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine;Varlitinib ARRY 334543;ARRY 334543 (Varlitinib);N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-Quinazoline diamine
Categories:
Biochemical Engineering > Inhibitors

Description

Varlitinib (ARRY-334543; ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.

ARRY-334543 Basic Attributes

Molecular Weight：

466.94326

Exact Mass：

466.097870

Characteristics

PSA：

122

XLogP3：

3.51

Density：

1.5±0.1 g/cm3

Boiling Point：

637.1±65.0 °C at 760 mmHg

Flash Point：

339.1±34.3 °C

Refractive Index：

1.742

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P304+P340, P305+P351+P338, P312, P330, P337+P313, P391, P403+P233, P405, P501

Hazard Statements：

H302

ARRY-334543 Use and Manufacturing

Varlitinibis a tyrosine kinase inhibitor being developed for the treatment of cancer. Varlitinib acts by disrupting the receptor tyrosine kinases ErbB-2, ErbB-4 and EGFR.

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ARRY334543(Varlitinib)

CAS No.: 845272-21-1

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