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BMS-794833

BMS-794833 structure

CAS No:
1174046-72-0
Formula:
C23H15ClF2N4O3
Chemical Name:
BMS-794833
Synonyms:
BMS-794833;3-PyridinecarboxaMide, N-[4-[(2-aMino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-;N-[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide;N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide;MS-794833;N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamideMS-794833;N-[4-(2-AMINO-3-CHLOROPYRIDIN-4-YL)OXY-3-FLUOROPHENYL]-5-(4-FLUOROPHENYL)-4-OXO-1H-PYRIDINE-3-CARBOXAMIDE;PDYXPCKITKHFOZ-UHFFFAOYSA-N
Categories:
Biochemical Engineering > Inhibitors

Description

BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.

BMS-794833 Basic Attributes

Molecular Weight：

468.8400064

Exact Mass：

468.080078

UNII：

SAY8KVM4HU

DSSTox ID：

DTXSID30657662

Characteristics

PSA：

106

XLogP3：

3.8

Density：

1.508

Boiling Point：

637.2±55.0 °C(Predicted)

Flash Point：

339.2±31.5 °C

Refractive Index：

1.681

BMS-794833 Use and Manufacturing

Methods of Manufacturing

To a solution of N-(4-(3-chloro-2-(diphenylmethyleneamino)pyridin-4- yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-l, 4-dihydropyridine-3-carboxamide (410 mg, 0.65 mmol) in THF (10 mL) at room temperature was added aqueous HCl (2 M, 0.81 mL, 1.62 mmol). The reaction mixture was stirred at room temperature for 1 h and then concentrated in vacuo. Cold 5percent aq. νaHCψ3 (5 mL) was then added to the residue. The solid that formed was collected by filtration, washed with water and then ether, and dried under vacuum to give the desired product (275 mg, 90percent).

Uses

BMS-794833 is a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor and it also inhibits Ron (Met family),Axl and Flt-3 with IC50 values <3 nM.

Computed Properties

Molecular Weight:468.8
XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:468.0800744
Monoisotopic Mass:468.0800744
Topological Polar Surface Area:106
Heavy Atom Count:33
Complexity:803
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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BMS-794833

CAS No.: 1174046-72-0

Content: 99.00%

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