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Ki8751

Ki8751 structure

CAS No:
228559-41-9
Formula:
C24H18F3N3O4
Chemical Name:
Ki8751
Synonyms:
Ki8751hydrate;N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea;1-(2,4-difluorophenyl)-3-(4-(6,7-diMethoxyquinolin-4-yloxy)-2-fluorophenyl)urea;N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea KI8751;Ki8751, >=98%;VEGFR2 Kinase Inhibitor VI, Ki8751;Ki8751;1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-ureahydrate
Categories:
Biochemical Engineering > Inhibitors

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Description

Ki8751 is a potent VEGFR2 inhibitor with an IC50 of 0.9 nM.

1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea is an aromatic ether.

Ki8751 Basic Attributes

Molecular Weight：

469.417

Exact Mass：

469.124939

UNII：

RP6UGT29FF

DSSTox ID：

DTXSID60462145

Characteristics

PSA：

81.7

XLogP3：

4.5

Density：

1.4±0.1 g/cm3

Melting Point：

239℃

Boiling Point：

497.1°C at 760 mmHg

Flash Point：

254.4±28.7 °C

Refractive Index：

1.657

Storage Conditions：

−20°C

Safety Information

hazard class code：

22-38

safety instructions：

Marks：

Drug Information

MeSH Entry Terms：

Ki 8751

Ki8751 Use and Manufacturing

Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

Computed Properties

Molecular Weight:469.4
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:469.12494055
Monoisotopic Mass:469.12494055
Topological Polar Surface Area:81.7
Heavy Atom Count:34
Complexity:677
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Ki8751

CAS No.: 228559-41-9

Content: 99%

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