 Home > Encyclopedia > ADX 47273

ADX 47273

ADX 47273 structure

CAS No:
851881-60-2
Formula:
C20H17F2N3O2
Chemical Name:
ADX 47273
Synonyms:
Methanone,(4-fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-;Piperidine,1-(4-fluorobenzoyl)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-,(3S)-;(4-Fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone;ADX 47273;(4-Fluorophenyl)-[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone
Categories:
Biochemical Engineering > Inhibitors

Description

ADX-47273 is a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).IC50 value: 170 nM(EC50) [1] [2]Target: positive allosteric modulator (PAM) of mGluR5in vitro: ADX-47273 increased (9-fold) the response to threshold concentration of glutamate (50 nM) in fluorometric Ca(2+) assays (EC(50) = 170 nM) in human embryonic kidney 293 cells expressing rat mGlu5. ADX47273 dose-dependently shifted mGlu5 receptor glutamate response curve to t

ADX 47273 Basic Attributes

Molecular Weight：

369.372

Exact Mass：

369.36

Characteristics

PSA：

59.2

XLogP3：

3.7

Density：

1.3±0.1 g/cm3

Flash Point：

280.9±32.9 °C

Refractive Index：

1.580