3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
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3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
structure -
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CAS No:
57477-39-1
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Formula:
C14H18N2O
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Chemical Name:
3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
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Synonyms:
1H-Indol-5-ol,3-(1-methyl-4-piperidinyl)-;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;BRL 54443
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CAS No:
Description
BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.IC50 value: 8.7(pKi, 5-HT1E); 8.9 (pKi, 5-HT1F) Target: 5-HT1E/1F receptorin vitro: BRL 54443 is a potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for
3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.
3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol Basic Attributes
230.31
230.31
Q2DH1CHI0Y
DTXSID40206089
2933990090
Computed Properties
Molecular Weight:230.31
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:230.141913202
Monoisotopic Mass:230.141913202
Topological Polar Surface Area:39.3
Heavy Atom Count:17
Complexity:263
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
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