2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
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![2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel- structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/9956ba721f9443618c7b08ff5ecc746f.png "2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-")
2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
structure -
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CAS No:
152520-56-4
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Formula:
C22H25F2NO4.ClH
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Chemical Name:
2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
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Synonyms:
2H-1-Benzopyran-2-methanol,α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride (1:1),(αR,α′R,2R,2′S)-rel-;2H-1-Benzopyran-2-methanol,α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride,[2R*[R*[R*(S*)]]]-(±)-;2H-1-Benzopyran-2-methanol,α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride,(αR,α′R,2R,2′S)-rel-;R 067555;2H-1-Benzopyran-2-methanol,α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-,hydrochloride,[2R*[R*[R*(S*)]]]-;Nebilet;Nebivolol hydrochloride;Nodon;Nebicard
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CAS No:
Description
White to Off-White Powder
(R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.|A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel- Basic Attributes
441.9
441.151855
1806241-263-5
DTXSID1049065
29322090
Characteristics
70.95000
3.55650
white to off-white
220-222°C
600.5°C at 760 mmHg
316.9ºC
DMSO: ≥20mg/mL
Desiccate at RT
2.88E-15mmHg at 25°C
Safety Information
3077
3
22-50/53
60-61
Xn,N
P273-P501
H302-H410
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P281, P301+P312, P308+P313, P330, P391, P405, and P501|Aggregated GHS information provided by 57 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Treatment of hypertension
Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Agonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
67555, R
2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel- Use and Manufacturing
Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM
Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:441.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:441.1518423
Monoisotopic Mass:441.1518423
Topological Polar Surface Area:71
Heavy Atom Count:30
Complexity:483
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
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