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MPEP

MPEP structure

CAS No:
96206-92-7
Formula:
C14H11N
Chemical Name:
MPEP
Synonyms:
Pyridine,2-methyl-6-(2-phenylethynyl)-;Pyridine,2-methyl-6-(phenylethynyl)-;2-Picoline,6-phenylethynyl-;2-Methyl-6-(2-phenylethynyl)pyridine;2-Methyl-6-(phenylethynyl)pyridine;MPEP
Categories:
Biochemical Engineering > Inhibitors

Description

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

MPEP Basic Attributes

Molecular Weight：

229.7

Exact Mass：

193.24

UNII：

7VC0YVI27Y

DSSTox ID：

DTXSID7042564|DTXSID9043982

HScode：

2933399090

Characteristics

PSA：

12.89000

XLogP3：

3.59180

Density：

1.10±0.1 g/cm3(Predicted)

Melting Point：

45-45.5 °C

Boiling Point：

124.5-126.5 °C @ Press: 0.5 Torr

Flash Point：

144.8ºC

Storage Conditions：

Desiccate at +4°C

Drug Information

MeSH：

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

MeSH Entry Terms：

2-methyl-6-(phenylethynyl)pyridine

MPEP Use and Manufacturing

A potent, subtype selective mGluR5 antagonist

Computed Properties

Molecular Weight:193.24
XLogP3:3.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:193.089149355
Monoisotopic Mass:193.089149355
Topological Polar Surface Area:12.9
Heavy Atom Count:15
Complexity:251
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 96206-92-7

Grade: Industrial Grade

Content: 99%

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