 Home > Encyclopedia > AT-13148

AT-13148

AT-13148 structure

CAS No:
1056901-62-2
Formula:
C17H16ClN3O
Chemical Name:
AT-13148
Synonyms:
AT-13148;(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol;(alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol;(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol;(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol AT13148;AT13148, >=98%;AT 13148 dihydrochloride;(1S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
Categories:
Biochemical Engineering > Inhibitors

Description

Multi-AGC Kinase Inhibitor AT13148 is an orally available, small molecule inhibitor of AGC group kinases, with potential antineoplastic activity. AT13148 inhibits, in an ATP-competitive manner, the enzymatic activity of two AGC kinases, protein kinase B (PKB or AKT) and p70S6K which play key roles in the PI3K/PKB/mTOR signaling pathway. Blockade of this pathway leads to an inhibition of cell growth and the induction of apoptosis in susceptible tumor cells. PI3K/PKB/mTOR pathway is dysregulated in greater than 50% of tumors, and is often correlated with resistance and increased tumor survival. AGC group kinases are serine/threonine kinases that are regulated by secondary messengers such as cyclic AMP and lipids.

AT-13148 Basic Attributes

Molecular Weight：

313.78144

Exact Mass：

313.098

UNII：

A49037RP1E

NCI Thesaurus Code：

C101786

HScode：

2933199090

Characteristics

PSA：

74.9

XLogP3：

2.2

Density：

1.328±0.06 g/cm3(Predicted)

Boiling Point：

595.9±50.0 °C(Predicted)

Drug Information

MeSH Entry Terms：

AT13148

Computed Properties

Molecular Weight:313.8
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:313.0981898
Monoisotopic Mass:313.0981898
Topological Polar Surface Area:74.9
Heavy Atom Count:22
Complexity:354
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of AT-13148

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

(1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol

CAS No.: 1056901-62-2

Content: 99.00%

Inquiry