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Bikinin

Bikinin structure

CAS No:
188011-69-0
Formula:
C9H9BrN2O3
Chemical Name:
Bikinin
Synonyms:
Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-;Bikinin;4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid;4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid;Abrasin;Bikinin(Abrasin)
Categories:
Biochemical Engineering > Inhibitors

Description

Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR (brassinosteroids) signaling.

Bikinin Basic Attributes

Molecular Weight：

273

Exact Mass：

271.979645

DSSTox ID：

DTXSID20349448

HScode：

2933399090

Characteristics

PSA：

79.3

XLogP3：

0.5

Appearance：

white to tan

Density：

1.711

Melting Point：

144°C(lit.)

Boiling Point：

521.6±45.0°C at 760 mmHg

Flash Point：

269.2±28.7 °C

Refractive Index：

1.635

Water Solubility：

DMSO: ≥5mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36

safety instructions：

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

GHS Classification：

|Warning|H302 (99.49%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 195 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

bikinin

Bikinin Use and Manufacturing

This ATP-competitive Arabidopsis GSK-3 inhibitor, (FW = 273.08 g/mol; CAS 188011-69-0), also named 4-(5-bromopyridin-2-ylamino)-4- oxobutanoic acid, is a strong activator of brassinosteroid (BR) signaling. Bikinin directly binds the GSK3 BIN2 and also inhibits the activity of six other Arabidopsis GSK3s. Genome-wide transcript analyses demonstrate that simultaneous inhibition of seven GSK3s is sufficient to activate BR responses. inhibited the SnRK2.3 kinase activity and its T180 phosphor

Computed Properties

Molecular Weight:273.08
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:271.97965
Monoisotopic Mass:271.97965
Topological Polar Surface Area:79.3
Heavy Atom Count:15
Complexity:248
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes