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Ferrostatin-1 (Fer-1)

Ferrostatin-1 (Fer-1) structure

CAS No:
347174-05-4
Formula:
C15H22N2O2
Chemical Name:
Ferrostatin-1 (Fer-1)
Synonyms:
Ethyl 3-amino-4-(cyclohexylamino)benzoate;Ferrostatin-1 (Fer-1);Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester
Categories:
Biochemical Engineering > Inhibitors

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Description

Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

Ferrostatin-1 (Fer-1) Basic Attributes

Molecular Weight：

262.34738

Exact Mass：

262.168121

HScode：

2922499990

Characteristics

PSA：

64.4

XLogP3：

3.3

Appearance：

faint purple to brown

Density：

1.1±0.1 g/cm3

Flash Point：

218.3±25.9 °C

Refractive Index：

1.595

Water Solubility：

DMSO: soluble10mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Ferrostatin-1 (Fer-1) Use and Manufacturing

The nitro derivative from above (24.28 g, 83 mmol) was hydrogenated (1 atm H2) over 20percent Pd(OH)2 on carbon (200 mg) in MeOH (150 mL) for 3 days. The catalyst was removed by filtration and volatiles removed under reduced pressure to give the title diamine (21.72 g, 100percent yield) as a dark purple solid.General procedure B (hydrogenolysis) [0274] The ethyl 4-(substituted-amino)-3-nitrobenzoates (130 mg, 0.445 mmol) were dissolved in MeOH (10 mL) and hydrogenated (H

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