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CPI-203

CPI-203 structure

CAS No:
1446144-04-2
Formula:
C19H18ClN5OS
Chemical Name:
CPI-203
Synonyms:
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide CPI 203;CPI 203(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-;(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic amide
Categories:
Biochemical Engineering > Inhibitors

Description

CPI-203 is a novel potent, selective and cell permeable inhibitor of BET bromodomain, with an IC50 value of appr 37 nM (BRD4 α-screen assay).

CPI-203 Basic Attributes

Molecular Weight：

399.89712

Exact Mass：

399.092072

Characteristics

PSA：

114

XLogP3：

2.9

Density：

1.51±0.1 g/cm3(Predicted)

Boiling Point：

690.4±65.0 °C(Predicted)

Flash Point：

371.4±34.3 °C

Refractive Index：

1.749

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH Entry Terms：

CPI203

Computed Properties

Molecular Weight:399.9
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:399.0920591
Monoisotopic Mass:399.0920591
Topological Polar Surface Area:114
Heavy Atom Count:27
Complexity:611
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes