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BI-D1870

BI-D1870 structure

CAS No:
501437-28-1
Formula:
C19H23F2N5O2
Chemical Name:
BI-D1870
Synonyms:
BI-D1870;2-[(3,5-difluoro-4-hydroxyphenyl)aMino]-5,7-diMethyl-8-(3-Methylbutyl)-5,6,7,8-tetrahydropteridin-6-one;6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-;2-[(3,5-DIFLUORO-4-HYDROXYPHENYL)AMINO]-7,8-DIHYDRO-5,7-DIMETHYL-8-(3-METHYLBUTYL)-6(5H)-PTERIDINONE
Categories:
Biochemical Engineering > Inhibitors

Description

BI-D1870 is an ATP-competitive inhibitor of RSK isoforms, with IC50s of 31 nM/24 nM/18 nM/15 nM for RSK1/SK2/SK3/SK4, respectively.

BI-D1870 Basic Attributes

Molecular Weight：

391.42

Exact Mass：

391.181976

NSC Number：

747342

DSSTox ID：

DTXSID40648506

Characteristics

PSA：

81.6

XLogP3：

3.6

Density：

1.3±0.1 g/cm3

Boiling Point：

579.3°C at 760 mmHg

Flash Point：

304.2±32.9 °C

Refractive Index：

1.585

Drug Information

MeSH Entry Terms：

BI D1870

BI-D1870 Use and Manufacturing

The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively). At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2. BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.

Computed Properties

Molecular Weight:391.4
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:391.18198132
Monoisotopic Mass:391.18198132
Topological Polar Surface Area:81.6
Heavy Atom Count:28
Complexity:542
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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BI-D1870

CAS No.: 501437-28-1

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