Farnesylthiosalicylic acid
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Farnesylthiosalicylic acid
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CAS No:
162520-00-5
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Formula:
C22H30O2S
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Chemical Name:
Farnesylthiosalicylic acid
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Synonyms:
Benzoic acid,2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-;Benzoic acid,2-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)thio]-,(E,E)-;Benzoic acid,2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]thio]-;2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid;S-Farnesylthiosalicylic acid;FTS;Salirasib;Farnesylthiosalicylic acid;748188-28-5
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CAS No:
Description
Pale Yellow Solid
Salirasib is a sesquiterpenoid.|Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung.|Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.
Characteristics
62.6
7.2
white to beige
1.05
64-66°C
486.0±45.0 °C(Predicted)
247.7±28.7 °C
1.559
DMSO: soluble20mg/mL, clear
-20°C Freezer
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
farnesylthiosalicylic acid
Farnesylthiosalicylic acid Use and Manufacturing
It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:358.5
XLogP3:7.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:358.19665137
Monoisotopic Mass:358.19665137
Topological Polar Surface Area:62.6
Heavy Atom Count:25
Complexity:498
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Farnesylthiosalicylic acid
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