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OG-L002

OG-L002 structure

CAS No:
1357302-64-7
Formula:
C15H15NO
Chemical Name:
OG-L002
Synonyms:
OG-L002;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;OG-L0024'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
Categories:
Biochemical Engineering > Inhibitors

Description

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IEgenes[1].

OG-L002 Basic Attributes

Molecular Weight：

225.29

Exact Mass：

225.115356

Characteristics

PSA：

46.2

XLogP3：

2.5

Density：

1.193±0.06 g/cm3(Predicted)

Boiling Point：

416.7±45.0 °C(Predicted)

Flash Point：

205.8±28.7 °C

Refractive Index：

1.644

Water Solubility：

H2O: Very slightly soluble (0.22 g/L) (25 ºC)

Computed Properties

Molecular Weight:225.28
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:225.115364102
Monoisotopic Mass:225.115364102
Topological Polar Surface Area:46.2
Heavy Atom Count:17
Complexity:260
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes