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BRD4770

BRD4770 structure

CAS No:
1374601-40-7
Formula:
C25H23N3O3
Chemical Name:
BRD4770
Synonyms:
BRD4770;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylateBRD4770;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester
Categories:
Biochemical Engineering > Inhibitors

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Description

2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles.

BRD4770 Basic Attributes

Molecular Weight：

413.477

Exact Mass：

413.174

EC Number：

-0

Characteristics

PSA：

73.2

XLogP3：

4.7

Appearance：

white to beige

Density：

1.21±0.1 g/cm3(Predicted)

Water Solubility：

DMSO: soluble5mg/mL, clear (warmed)

Storage Conditions：

2-8°C

Safety Information

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

BRD4770

BRD4770 Use and Manufacturing

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]

Computed Properties

Molecular Weight:413.5
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:413.17394160
Monoisotopic Mass:413.17394160
Topological Polar Surface Area:73.2
Heavy Atom Count:31
Complexity:601
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes