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Home > Encyclopedia > N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine

N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine

N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine structure

N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine 

structure
  • CAS No:

    945595-80-2

  • Formula:

    C28H21N7OS

  • Chemical Name:

    N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine

  • Synonyms:

    1-Phthalazinamine,N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-;N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine;AMG 900

  • Categories:

    Biochemical Engineering  >  Inhibitors

Description

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.

N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine Basic Attributes

503.59

503.58

-0

9R2G075611

DTXSID90241526

Characteristics

140

5.1

1.4±0.1 g/cm3

424.7±35.7 °C

1.739

Drug Information

AMG 900

Computed Properties

Molecular Weight:503.6
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:503.15282949
Monoisotopic Mass:503.15282949
Topological Polar Surface Area:140
Heavy Atom Count:37
Complexity:725
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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