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Otilonium bromide

Otilonium bromide structure

CAS No:
26095-59-0
Formula:
C29H43N2O4.Br
Chemical Name:
Otilonium bromide
Synonyms:
Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-,bromide (1:1);Ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,p-[o-(octyloxy)benzamido]benzoate;Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-,bromide;Benzoic acid,p-[o-(octyloxy)benzamido]-,ester with diethyl(2-hydroxyethyl)methylammonium bromide;Otilonium bromide;Spasmomen;Octylonium bromide;SP 63
Categories:
Biochemical Engineering > Inhibitors

Description

Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.Target: mAChROtilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM) [1]. Otilonium, a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR). Whole-cell Ba2+ currents (IBa) through Ca2+ channels of voltage-clamped chromaffin cells were blocked by otilonium with an IC50 of 6.4 microM. Otilonium inhibited the

Otilonium bromide Basic Attributes

Molecular Weight：

563.57

Exact Mass：

562.240601

EC Number：

247-457-4

UNII：

21HN3N72PV

DSSTox ID：

DTXSID0046357

ATC Code：

A03AB06|A - Alimentary tract and metabolism

HScode：

2923900090

Characteristics

PSA：

64.6

Melting Point：

130-133°C

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 in mice (mg/kg) 87.0 i.p.

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

N-diethylmethylammoniummethyl-p-(2-(N-octyloxy)benzoyl)aminobenzoate bromide

Otilonium bromide Use and Manufacturing

Inhibits platlet activating factor induced hypotension. Antispasmodic

Computed Properties

Molecular Weight:563.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:17
Exact Mass:562.24062
Monoisotopic Mass:562.24062
Topological Polar Surface Area:64.6
Heavy Atom Count:36
Complexity:600
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Spammin belongs to a class of antispasmodic and anticholinergic drugs (ATC number: A03AB06). This drug has a selective and strong antispasmodic effect on the smooth muscle of the digestive tract, so it is suitable for all hyperkinesia, spasmodic reactions caused by different causes and different parts, and pathological atrophy of smooth muscle fibers.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Otilonium Bromide Tablets
Ingredients	Otilonium Bromide
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	40 mg

Otilonium Bromide Tablets
Ingredients	Otilonium bromide.
Indication	Not yet clear.
Specifications	40mg*20s

Otilonium Bromide
Specifications	API
Manufacturer	Jincheng Haisi Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

SYMED LABS LTD

United States
Active
OLON S.P.A.

Italy
Active
Jincheng Haisi Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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