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PCI 34051

PCI 34051 structure

CAS No:
950762-95-5
Formula:
C17H16N2O3
Chemical Name:
PCI 34051
Synonyms:
N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;PCI 34051;PCI-34051;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Categories:
Biochemical Engineering > Inhibitors

Description

PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

PCI 34051 Basic Attributes

Molecular Weight：

296.32054

Exact Mass：

296.116089

Characteristics

PSA：

63.5

XLogP3：

2.4

Density：

1.3±0.1 g/cm3

Refractive Index：

1.621

Storage Conditions：

2-8°C

Safety Information

hazard class code：

22-36

safety instructions：

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, P501

Hazard Statements：

H302

PCI 34051 Use and Manufacturing

PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Recommended Suppliers of PCI 34051

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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PCI 34051

CAS No.: 950762-95-5

Content: 99.00%

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Creative Enzymes Contact Supplier

US
6 YRS

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PCI 34051

CAS No.: 950762-95-5

Content: 98%

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