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5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone structure

CAS No:
403811-55-2
Formula:
C12H11NOS2
Chemical Name:
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Synonyms:
4-Thiazolidinone,5-[(4-ethylphenyl)methylene]-2-thioxo-;5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone;10058F4
Categories:
Biochemical Engineering > Inhibitors

Description

10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

10058-F4 is a member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase. It has a role as an apoptosis inducer and an antineoplastic agent. It is a thiazolidinone and an olefinic compound.

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone Basic Attributes

Molecular Weight：

249.36

Exact Mass：

249.35

HScode：

2934100090

Characteristics

PSA：

86.5

XLogP3：

3.6

Appearance：

yellow

Density：

1.3±0.1 g/cm3

Boiling Point：

387.1°C at 760 mmHg

Flash Point：

187.9±30.7 °C

Refractive Index：

1.664

Water Solubility：

soluble in DMSO(>10mg/mL). soluble in water at concentrations less than 2mg/ml

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36-43

safety instructions：

26-36/37

Marks：

Precautionary statement(s)：

P280-P305 + P351 + P338

Hazard Statements：

H317-H319

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

10058-F4 compound

Computed Properties

Molecular Weight:249.4
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:249.02820632
Monoisotopic Mass:249.02820632
Topological Polar Surface Area:86.5
Heavy Atom Count:16
Complexity:330
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Latest News on 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

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Guide of 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Latest News
Learn More Other Chemicals

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

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