 Home > Encyclopedia > Torcetrapib

Torcetrapib

Torcetrapib structure

CAS No:
262352-17-0
Formula:
C26H25F9N2O4
Chemical Name:
Torcetrapib
Synonyms:
1(2H)-Quinolinecarboxylic acid,4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-,ethyl ester,(2R,4S)-;CP 529414;Torcetrapib;(2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester;(2R,4S)-4-[[3,5-Bis(trifluoromethyl)benzyl]methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester;(-)-Torcetrapib
Categories:
Biochemical Engineering > Inhibitors

Description

Torcetrapib(CP-529414) is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma.IC50 value: 37 nM [1]Target: CETP inhibitorin vitro: Torcetrapib dose-dependently increases aldosterone release from H295R cells after either 24 or 48 h of treatment with an EC50 of approximately 80 nM, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. Torcetrapib (1 μM) significantl

Torcetrapib is a member of quinolines, a carbamate ester and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.|Torcetrapib (CP-529414, Pfizer) was developed to treat hypercholesterolemia but its development was halted in 2006 when phase III studies showed excessive mortality in the treatment group receiving a combination of atorvastatin and the study drug.|Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to excess deaths.

Torcetrapib Basic Attributes

Molecular Weight：

603.49

Exact Mass：

600.47

UNII：

4N4457MV2U

DSSTox ID：

DTXSID20180873

NCI Thesaurus Code：

C91058

Characteristics

PSA：

59.1

XLogP3：

7.76

Appearance：

white

Density：

1.4±0.1 g/cm3

Melting Point：

54-58 °C

Boiling Point：

504.8±50.0 °C at 760 mmHg

Flash Point：

259.1±30.1 °C

Refractive Index：

1.512

Water Solubility：

DMSO: >5mg/mL

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

Drug Indication：

Investigated for use/treatment in peripheral vascular disease and hyperlipidemia.

MeSH：

Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)

Mechanism of Action：

Torcetrapib is an inhibitor of cholesteryl ester-transfer protein (CETP) that increases high-density lipoprotein (HDL) cholesterol levels. The drug increases HDL-cholesterol and apolipoprotein A-I levels and decreases LDL-cholesterol and apolipoprotein B levels. The effect is showed in monotherapy and when administered in combination with statins.

MeSH Entry Terms：

CP 529,414

Torcetrapib Use and Manufacturing

Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.

Computed Properties

Molecular Weight:600.5
XLogP3:7
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:7
Exact Mass:600.16706074
Monoisotopic Mass:600.16706074
Topological Polar Surface Area:59.1
Heavy Atom Count:41
Complexity:889
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Torcetrapib

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Torcetrapib

CAS No.: 262352-17-0

Content: 99.00%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

99% torcetrapib CAS NO 262352-17-0 ISO 9001:2005 REACH Verified Producer

CAS No.: 262352-17-0

Grade: Industrial Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Torcetrapib

CAS No.: 262352-17-0

Content: 95%

Inquiry