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Varespladib

Varespladib structure

CAS No:
172732-68-2
Formula:
C21H20N2O5
Chemical Name:
Varespladib
Synonyms:
Acetic acid,2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-;Acetic acid,[[3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-;2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid;LY 315920;Varespladib;[[3-(2-Amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
Categories:
Biochemical Engineering > Inhibitors

Description

LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.IC50 value: 7 nMTarget: sPLA2in vitro: LY315920 exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50 of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. [2] In BAL cells challenged with human sPLA2, LY315920 at doses ranging from 0.1 μM–3 μM reduces the formation of t

Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome.

Varespladib Basic Attributes

Molecular Weight：

380.398

Exact Mass：

380.39

EC Number：

1592732-453-0

UNII：

2Q3P98DATH

DSSTox ID：

DTXSID50169378

Characteristics

PSA：

112

XLogP3：

2.45

Density：

1.32±0.1 g/cm3(Predicted)

Melting Point：

230-234 °C

Boiling Point：

667.9±65.0 °C(Predicted)

Flash Point：

357.7±34.3 °C

Refractive Index：

1.630

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

((3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetate

Varespladib Use and Manufacturing

This compound is used as a PLA2 inhibitor (Phospholipase A2 Enzyme inhibitor).

Computed Properties

Molecular Weight:380.4
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:380.13722174
Monoisotopic Mass:380.13722174
Topological Polar Surface Area:112
Heavy Atom Count:28
Complexity:589
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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LY315920(Varespladib)

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