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NLG919

NLG919 structure

CAS No:
1402836-58-1
Formula:
C18H22N2O
Chemical Name:
NLG919
Synonyms:
NLG919;5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-;1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol NLG919;NLG9191-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL;alpha-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol;NLG919, >=98%
Categories:
Biochemical Engineering > Inhibitors

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NLG919 Basic Attributes

Molecular Weight：

282.39

Exact Mass：

282.173

EC Number：

1592732-453-0

Characteristics

PSA：

XLogP3：

3.5

Density：

1.27±0.1 g/cm3(Predicted)

Boiling Point：

524.6±33.0 °C(Predicted)

NLG919 Use and Manufacturing

At 0° C., to a solution of 1-cyclohexyl-2-[5H-imidazo[4, 3-a]isoindol-5-yl]ethan-1-one (300 mg, 1.07 mmol) in methanol (5 mL) was added sodium borohydride (81 mg, 2.14 mmol) slowly. The resulting reaction mixture was kept stirring at 0° C. for 30 min. The reaction mixture was then quenched by water (30 mL) and the mixture was extracted with ethyl acetate (50 mL*2). The organic phases were combined, washed with brine, and dried over NaTo a single-necked flask was added 1-cyclohexyl-2- (5H-imidazo [5, 1-a] isoindole-5-) ethanone (140 mg, 0.5 mmol)And methanol (3 ml)At 0 sodium borohydride (57mg, 1.5mmol), After stirring for 1 h, the solvent was dried, 2N hydrochloric acid (3 ml) was added, Extracted with ethyl acetate, the combined organic layers were dried over anhydrous sodium sulfate, the solvent was concentrated, Purification by chromatography on silica gel afforded compound 10 (105 mg, yield 73percent, LCMS purity 99.0percent)

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NLG919

CAS No.: 1402836-58-1

Content: 99.00%

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