Degrasyn
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Degrasyn
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CAS No:
856243-80-6
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Formula:
C19H18BrN3O
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Chemical Name:
Degrasyn
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Synonyms:
2-Propenamide,3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-,(2E)-;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide;Degrasyn;WP 1130;WPI 130
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CAS No:
Description
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
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