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JNJ-7706621

JNJ-7706621 structure

CAS No:
443797-96-4
Formula:
C15H12F2N6O3S
Chemical Name:
JNJ-7706621
Synonyms:
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide;Aurora Kinase/Cdk Inhibitor
Categories:
Biochemical Engineering > Inhibitors

Description

JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC50s of 9, 3, 11, and 15 nM for CDK1, CDK2, Aurora-A and Aurora-B, respectively.

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.

JNJ-7706621 Basic Attributes

Molecular Weight：

394.36

Exact Mass：

394.065979

UNII：

74GK72DON8

DSSTox ID：

DTXSID40416207

HScode：

2935009090

Characteristics

PSA：

154

XLogP3：

2.4

Density：

1.7±0.1 g/cm3

Melting Point：

149-155℃

Boiling Point：

676.6±65.0 °C at 760 mmHg

Flash Point：

363.0±34.3 °C

Refractive Index：

1.724

Water Solubility：

Soluble in DMSO at 15mg/ml

Drug Information

MeSH Entry Terms：

JNJ-7706621

Computed Properties

Molecular Weight:394.4
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:394.06596576
Monoisotopic Mass:394.06596576
Topological Polar Surface Area:154
Heavy Atom Count:27
Complexity:630
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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JNJ-7706621

CAS No.: 443797-96-4

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