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G-749

G-749 structure

CAS No:
1457983-28-6
Formula:
C25H25BrN6O2
Chemical Name:
G-749
Synonyms:
G-749;8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one;8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-oneG749;G-749, >=98%;G-49;G-749 (Free base)
Categories:
Biochemical Engineering > Inhibitors

Description

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.

G-749 Basic Attributes

Molecular Weight：

521.409

Exact Mass：

520.122253

UNII：

B06W426B66

Characteristics

PSA：

91.4

XLogP3：

4.9

Density：

1.487±0.06 g/cm3(Predicted)

Refractive Index：

1.701

Water Solubility：

H2O: Insuluble (8.3E-5 g/L) (25 ºC)

Computed Properties

Molecular Weight:521.4
XLogP3:4.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:520.12224
Monoisotopic Mass:520.12224
Topological Polar Surface Area:91.4
Heavy Atom Count:34
Complexity:716
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes