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NVP-HSP990(HSP990)

NVP-HSP990(HSP990) structure

CAS No:
934343-74-5
Formula:
C20H18FN5O2
Chemical Name:
NVP-HSP990(HSP990)
Synonyms:
NVP-HSP990(HSP990);HSP-990;NVP-HSP990;(R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one;(7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one;HSP990 (NVP-HSP990);(7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d
Categories:
Biochemical Engineering > Inhibitors

Description

NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

NVP-HSP990(HSP990) Basic Attributes

Molecular Weight：

379.3876232

Exact Mass：

379.144440

UNII：

E0WBA7B62L

DSSTox ID：

DTXSID50239429

HScode：

29339900

Characteristics

PSA：

103

XLogP3：

2.1

Density：

1.3±0.1 g/cm3

Refractive Index：

1.627

Drug Information

MeSH Entry Terms：

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one

Computed Properties

Molecular Weight:379.4
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:379.14445300
Monoisotopic Mass:379.14445300
Topological Polar Surface Area:103
Heavy Atom Count:28
Complexity:567
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes