N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
-
![N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/7a8d9106d3aa4c1d88c8b0b743bdc5c3.png "N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide")
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
structure -
-
CAS No:
313553-47-8
-
Formula:
C18H16N2OS
-
Chemical Name:
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
-
Synonyms:
Benzamide,N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide;IBT 13131;INH 1
- Categories:
-
CAS No:
Description
INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1]Target: Hec1 inhibitorTreating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently leading to metaphase chromosome misalignment, spindle aberrancy, and eventual cell death. INH1 effectively inhibited the proliferation of multiple human breast canc
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide Use and Manufacturing
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide is a small molecule that targets the Hec1/Nek2 pathway and was found to effectively inhibit the proliferation of multiple human breast cancer cell lines in culture and in animal.
Computed Properties
Molecular Weight:308.4
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:308.09833431
Monoisotopic Mass:308.09833431
Topological Polar Surface Area:70.2
Heavy Atom Count:22
Complexity:383
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
-
![China]()
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 313553-47-8Grade: Industrial GradeContent: 95%
Latest News on N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
Dabrafenib
1195765-45-7
-
BOC-VAL-VAL-OH
69209-73-0
-
BMS 303141
943962-47-8
-
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanamide Formula
60117-17-1
-
(2S)-2-acetamido-6-amino-N-[(2S)-2-amino-3-methylbutanoyl]-N-propylhexanamide Formula
57899-96-4
-
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea Formula
26130-02-9
-
L-Tyrosyl-L-phenylalanine Structure
17355-11-2
-
C-REACTIVE PROTEIN FRAGMENT 77-82 Structure
130349-01-8
-
What is Sildenafil
139755-83-2
-
What is Dacomitinib
1110813-31-4
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
SDSRequest for Quotation