 Home > Encyclopedia > 6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine

6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine

6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine structure

CAS No:
934353-76-1
Formula:
C21H25N7
Chemical Name:
6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine
Synonyms:
6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine;ENMD-2076;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine;6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamineENMD-2076
Categories:
Biochemical Engineering > Inhibitors

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Description

ENMD-2076 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.

6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine Basic Attributes

Molecular Weight：

375.4701

Exact Mass：

375.217133

UNII：

J6U9WP10T7

DSSTox ID：

DTXSID90735339|DTXSID60239430

Characteristics

PSA：

XLogP3：

1.31

Density：

1.3±0.1 g/cm3

Boiling Point：

535.0±50.0 °C at 760 mmHg

Flash Point：

277.4±30.1 °C

Refractive Index：

1.704

Drug Information

MeSH Entry Terms：

ENMD 2076

Computed Properties

Molecular Weight:375.5
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:375.21714383
Monoisotopic Mass:375.21714383
Topological Polar Surface Area:73
Heavy Atom Count:28
Complexity:499
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine

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ENMD-2076

CAS No.: 934353-76-1

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CAS No.: 934353-76-1

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Guide of 6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

6-(4-Methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]-4-pyrimidinamine

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