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TCS 359

TCS 359 structure

CAS No:
301305-73-7
Formula:
C18H20N2O4S
Chemical Name:
TCS 359
Synonyms:
2-(3,4-DIMETHOXY-BENZOYLAMINO)-4,5,6,7-T;TCS359;2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylicacidamide;Flt-3inhibitor;2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide;2-(3,4-diMethoxybenzaMido)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxaMide;Benzo[b]thiophene-3-carboxaMide,2-[(3,4-diMethoxybenzoyl)aMino]-4,5,6,7-tetrahydro-;2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide
Categories:
Biochemical Engineering > Inhibitors

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Description

2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide is a dimethoxybenzene.

TCS 359 Basic Attributes

Molecular Weight：

360.432

Exact Mass：

360.114

DSSTox ID：

DTXSID60359965

Characteristics

PSA：

119

XLogP3：

3.4

Appearance：

white to off-white

Density：

1.328±0.06 g/cm3(Predicted)

Boiling Point：

454.4ºC at 760mmHg

Flash Point：

228.6ºC

Refractive Index：

1.644

Water Solubility：

H2O: <2mg/mL

Storage Conditions：

−20°C

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

TCS 359 Use and Manufacturing

Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer.FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 μM). It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.

Computed Properties

Molecular Weight:360.4
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:360.11437830
Monoisotopic Mass:360.11437830
Topological Polar Surface Area:119
Heavy Atom Count:25
Complexity:504
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 301305-73-7

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CAS No.: 301305-73-7

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