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AZD2461

AZD2461 structure

CAS No:
1174043-16-3
Formula:
C22H22FN3O3
Chemical Name:
AZD2461
Synonyms:
AZD2461;4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one;1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-;AZD 2461, >=98%
Categories:
Biochemical Engineering > Inhibitors

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Description

AZD-2461 is a potent PARP inhibitor, with IC50s of 5 nM, 2 nM and 200 nM for PARP1, PARP2 and PARP3, respectively.

AZD2461 Basic Attributes

Molecular Weight：

395.4267832

Exact Mass：

395.164520

Characteristics

PSA：

XLogP3：

2.6

Density：

1.33±0.1 g/cm3(Predicted)

Refractive Index：

1.640

Safety Information

Precautionary statement(s)：

P260, P264, P270, P301+P312, P314, P330, P501

Hazard Statements：

H302

AZD2461 Use and Manufacturing

Methods of Manufacturing

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (231 g, 1206.97 mmol) was added to 4-methoxypiperidine hydrochloride (183 g, 1206.97 mmol), 2-fluoro-5-((4-oxo-3, 4-dihydrophthalazin-1-yl)methyl)benzoic acid (300 g, 1005.80 mmol) and 4-dimethylaminopyridine (30.7 g, 251.45 mmol) in DCM (4 L) at 23° C. The resulting suspension was stirred at room temperature over night. The reaction mixture was washed with 2M HCl (5 L) and 50percent saturated sodium carbonate (3 L) before being dried over MgSOa)

Uses

4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.

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AZD2461

CAS No.: 1174043-16-3

Content: 0.98%

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1174043-16-3 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one

CAS No.: 1174043-16-3

Grade: Industrial Grade

Content: 95%

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