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VX-222

VX-222 structure

CAS No:
1026785-59-0
Formula:
C25H35NO4S
Chemical Name:
VX-222
Synonyms:
VX-222;5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid;VCH 222;VCH222;VCH-222;VX-222, VCH222;VX-222 (VCH-222, LoMibuvir);2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
Categories:
Biochemical Engineering > Inhibitors

Description

VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.IC50 Value: 0.94 μM (HCV NS5B 1a); 1.2 μM (HCV NS5B 1b)Target: HCVVX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. VX-222 exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1

VX-222 Basic Attributes

Exact Mass：

445.228668

EC Number：

-0

Characteristics

PSA：

106.08000

XLogP3：

5.15

Density：

1.21

Boiling Point：

640.5±55.0 °C(Predicted)

Flash Point：

341.2±31.5 °C

Refractive Index：

1.589

Recommended Suppliers of VX-222

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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VX-222

CAS No.: 1026785-59-0

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Creative Enzymes Contact Supplier

US
6 YRS

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VX-222(VCH-222, Lomibuvir)

CAS No.: 1026785-59-0

Content: 0.98%

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