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AZD-4547

AZD-4547 structure

CAS No:
1035270-39-3
Formula:
C26H32N5O3
Chemical Name:
AZD-4547
Synonyms:
AZD-4547;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide;AZD4547/AZD-4547;AZD4547, Free Base, >99%;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamideAZD4547;N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-rel-3,5-dimethylpiperazin-1-yl)benzamide;rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide;AZD4547, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

Pale Yellow SolidAZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.

AZD-4547 Basic Attributes

Molecular Weight：

462.56398

Exact Mass：

463.258331

Characteristics

PSA：

91.5

XLogP3：

3.9

Density：

1.189

Boiling Point：

621.7±55.0 °C(Predicted)

Flash Point：

329.8±31.5 °C

Refractive Index：

1.602

Safety Information

Precautionary statement(s)：

P260, P264, P270, P301+P310, P301+P312, P314, P321, P330, P405, P501

Hazard Statements：

H301

AZD-4547 Use and Manufacturing

AZD4547 is abioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine kinases and is under clinical investigation for the treatment of FGFR-dependent tumors.

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AZD-4547

CAS No.: 1035270-39-3

Content: 99.00%

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