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Calpeptin

Calpeptin structure

CAS No:
117591-20-5
Formula:
C20H30N2O4
Chemical Name:
Calpeptin
Synonyms:
Carbamic acid,N-[(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-,phenylmethyl ester;Carbamic acid,[1-[[(1-formylpentyl)amino]carbonyl]-3-methylbutyl]-,phenylmethyl ester,[S-(R*,R*)]-;Carbamic acid,[(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-,phenylmethyl ester;Calpeptin;N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinal
Categories:
Biochemical Engineering > Inhibitors

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Description

white to off-white powder

Calpeptin is an amino acid amide.

Calpeptin Basic Attributes

Molecular Weight：

362.46

Exact Mass：

362.46

UNII：

18X9FR245W

HScode：

29242990

Characteristics

PSA：

84.5

XLogP3：

3.9

Appearance：

white to beige

Density：

1.1667 (rough estimate)

Melting Point：

60-75 °C

Boiling Point：

494.07°C (rough estimate)

Flash Point：

286.8±28.7 °C

Refractive Index：

1.6800 (estimate)

Water Solubility：

Soluble in DMSO at 15mg/ml

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

Drug Information

MeSH：

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. (See all compounds classified as Cysteine Proteinase Inhibitors.)

MeSH Entry Terms：

benzylcarbonyl-Leu-nLeu-H

Calpeptin Use and Manufacturing

Potent, cell-permeable inhibitor of the Ca 2+ -dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Computed Properties

Molecular Weight:362.5
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:362.22055744
Monoisotopic Mass:362.22055744
Topological Polar Surface Area:84.5
Heavy Atom Count:26
Complexity:434
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Calpeptin

CAS No.: 117591-20-5

Content: 99.00%

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