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PI-1840

PI-1840 structure

CAS No:
1401223-22-0
Formula:
C22H26N4O3
Chemical Name:
PI-1840
Synonyms:
PI-1840;N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide;N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-acetamide
Categories:
Biochemical Engineering > Inhibitors

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PI-1840 Basic Attributes

Molecular Weight：

394.46684

Exact Mass：

394.2

Characteristics

PSA：

81.4

XLogP3：

3.9

Drug Information

MeSH Entry Terms：

PI-1840

PI-1840 Use and Manufacturing

This potent proteasome inhibitor (FW = 394.38 g/mol) selectively targets its chymotrypsin-like activity, or CT-L (IC50 = 27 nM), while showing much weaker action (IC50 values >100 μM) against its Trypsin-Like (T-L) and peptidylglutamyl peptide hydrolyzing, or PGPH activities. Mass spectrometry and equilibrium dialysis show no evidence of covalent linkage of PI-1840 with any proteasomal protein component. In intact cancer cells, PI-1840 inhibits CT-L activity, inducing the accumulation of protea

Computed Properties

Molecular Weight:394.5
XLogP3:3.9
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:394.20049070
Monoisotopic Mass:394.20049070
Topological Polar Surface Area:81.4
Heavy Atom Count:29
Complexity:496
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes