 Home > Encyclopedia > AZD 9668

AZD 9668

AZD 9668 structure

CAS No:
848141-11-7
Formula:
C25H22F3N5O4S
Chemical Name:
AZD 9668
Synonyms:
Alvelestat;AZD 9668;AZD9668;AZD-9668;Avelestat (AZD9668);6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide;Avelestat;Alvelestat (AZD9668)
Categories:
Biochemical Engineering > Inhibitors

Description

Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease.|Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity. Upon administration, alvelestat binds to and inhibits the activity of human NE. This inhibits NE-mediated inflammatory responses, which may prevent lung inflammation and injury, and may improve lung function associated with NE-induced respiratory diseases. NE, a serine protease released by neutrophils during inflammation, is upregulated in a number of respiratory diseases.

AZD 9668 Basic Attributes

Molecular Weight：

545.5334896

Exact Mass：

545.134

UNII：

6Y5629322X

DSSTox ID：

DTXSID40233875

NCI Thesaurus Code：

C125714

Characteristics

PSA：

123

XLogP3：

2.5

Density：

1.42±0.1 g/cm3(Predicted)

Drug Information

MeSH Entry Terms：

AZD9668

Computed Properties

Molecular Weight:545.5
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:545.13445986
Monoisotopic Mass:545.13445986
Topological Polar Surface Area:123
Heavy Atom Count:38
Complexity:1100
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of AZD 9668

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Alvelestat

CAS No.: 848141-11-7

Content: 99.00%

Inquiry